Inhibition of a TREK-like K channel current by noradrenaline requires both b1- and b2-adrenoceptors in rat atrial myocytes

نویسندگان

  • Richard C. Bond
  • Stéphanie C.M. Choisy
  • Simon M. Bryant
  • Jules C. Hancox
  • Andrew F. James
چکیده

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Inhibition of a TREK-like K channel current by noradrenaline requires both b1and b2-adrenoceptors in rat atrial myocytes

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Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes

AIMS Noradrenaline plays an important role in the modulation of atrial electrophysiology. However, the identity of the modulated channels, their mechanisms of modulation, and their role in the action potential remain unclear. This study aimed to investigate the noradrenergic modulation of an atrial steady-state outward current (IKss). METHODS AND RESULTS Rat atrial myocyte whole-cell currents...

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Many members of the two-pore-domain potassium (K(+)) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We investigated whether I(KAA), a background K(+) current activated by negative pressure (stretch) and by arachidonic acid (AA) and sensitive to intracellular acidification, could be the native correlate of TRE...

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A TREK-1–Like Potassium Channel in Atrial Cells Inhibited by b-Adrenergic Stimulation and Activated by Volatile Anesthetics

Many members of the two-pore-domain potassium (K) channel family have been detected in the mammalian heart but the endogenous correlates of these channels still have to be identified. We investigated whether IKAA, a background K current activated by negative pressure (stretch) and by arachidonic acid (AA) and sensitive to intracellular acidification, could be the native correlate of TREK-1 in a...

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The regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using HPLC methods. Noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. The response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relativ...

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The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle.

OBJECTIVE The biophysical properties and the regulation of the two-pore-domain potassium channel TREK-1 were studied in rat cardiomyocytes. METHODS RT-PCR, immunohistochemistry and patch-clamp recording were performed in isolated rat ventricular cardiomyocytes. In some whole-cell-clamp experiments the myocytes were mechanically stretched using a glass stylus. RESULTS We found strong express...

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تاریخ انتشار 2014